As presented at a poster session at the 2007 American Psychiatric Association (APA) conference, “APA: SSRIs in Pregnancy Not Associated With Cardiac or Pulmonary Problems”–there is a prelimiary data which offers encouraging support for the use of SSRIs during pregnancy. As reported in MedpageToday.com:
“In a retrospective review of records of more than 25,000 pregnant women treated at the Mayo Clinic in Rochester, Minn., from 1993 through 2005, there was no association between the mothers’ SSRI use during pregnancy and the occurrence of congenital heart disease, ventricular septal defects, or persistent pulmonary hypertension in their children, reported Christina L. Wichman, D.O., and colleagues at the American Psychiatric Association meeting here. ” Here’s the entire article in Medpage Today.
While a retrospective chart review isn’t the best methodology (it’s certainly the best bet for pregnancy), this is very positive and evidence-based study with a large number of patients, supporting the safety of SSRIs in pregnancy.
As noted in a side-bar, “These data and conclusions should be considered to be preliminary until published in a peer-reviewed publication.”